罗娇 助理教授

来源: 发布时间:2021-12-21 15:30:43

  

4DAB4


  罗娇,女,1990年10月生,安徽宿州人。2018年6月毕业于中国科学院海洋研究所,海洋生物学博士。现为betway必威助理教授,青年卓越人才,硕士生导师。

一、主要研究方向

1. 酒精性肝损伤的毒作用机制及干预研究(表观遗传及蛋白功能研究方向);

2. 基于单细胞转录组的酒精肝数据挖掘及分子机制研究;

二、代表性科研成果

1)近5年学术论文(一作/共同一作)

1. Luo, J.#, Song, G.#, Chen, N.#, Xie, M., Niu, X., Zhou, S., ... & Yu, D. (2023). Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation. Cell Death Discovery, 9(1), 311.

2. Luo, J.#, Ji, Y.#, Chen, N., Song, G., Zhou, S., Niu, X., & Yu, D. (2023). Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter. iScience, 26(10).

3. Chen, N.#, Luo, J#., Zhou, T., Shou, Y., Du, C., Song, G., ... & Yu, D. (2023). Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease. Biochemical Pharmacology, 115936.

4. Chen, N.#, Luo, J.#, Hou, Y.#, Ji, Y., Xie, M., Song, G., & Yu, D. * (2022). miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer. Biochemical Pharmacology, 203, 115182.

5. Luo, J.#, Hou, Y. #, Ma, W., Xie, M., Jin, Y., Xu, L., ... & Yu, D.* (2021). A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells. Biochemical Pharmacology, 189, 114458.

6. Luo, J. #, Xie, M.#, Hou, Y., Ma, W., Jin, Y., Chen, J., ... & Yu, D.* (2021). A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease. Biochemical Pharmacology, 188, 114582.

7. Jiang, B. #, Luo, J. #, Guo, S., & Wang, L. * (2021). Discovery of 5-(3-bromo-2-(2, 3-dibromo-4, 5-dimethoxybenzyl)-4, 5-dimethoxybenzylidene) thiazolidine-2, 4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties. Bioorganic Chemistry, 108, 104648.

8. Luo, J., Zheng, M., Jiang, B., Li, C., Guo, S., Wang, L., ... & Shi, D.* (2020). Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides. British Journal of Pharmacology, 177(19), 4464-4480.

9. Luo, J., Zhang, R., Wang, X., Hou, Z., Guo, S., & Jiang, B.* (2020). Binding properties of marine bromophenols with human protein tyrosine phosphatase 1B: Molecular docking, surface plasmon resonance and cellular insulin resistance study. International Journal of Biological Macromolecules, 163, 200-208.

10. Luo, J., Jiang, B., Li, C., Jia, X., & Shi, D.* (2019). CYC27 synthetic derivative of bromophenol from red alga Rhodomela confervoides: anti-diabetic effects of sensitizing insulin signaling pathways and modulating RNA splicing-associated RBPs. Marine drugs, 17(1), 49.

11. Ma, X.#, Zhang, X.#, Luo, J.#, Liang, B., Peng, J., Chen, C., ... & Xiao, Y.* (2020). MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells. Toxicology in Vitro, 66, 104830.

12. Luo, J., Xu, Q., Jiang, B., Zhang, R., Jia, X., Li, X., ... & Shi, D.* (2018). Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor. British journal of pharmacology, 175(1), 140-153.

2)发明专利

1.于典科,罗娇,赵艳洁,靳远,郑玉新;用于检测甲基化对miRNA和mRNA结合影响的方法;申请号:201910449084.X。

三、主要科研项目

1. 国家自然科学基金委员会,面上项目,82273670,基于单细胞转录组研究肝窦内皮细胞JAM2高表达致酒精肝相关免疫细胞跨内皮迁移浸润的作用机制,2023-01至2026-12,52万元,在研,主持;

2. 国家自然科学基金委员会,青年项目,81903354,miR-29c通过非经典模式调控酒精性肝损伤的作用机制研究,2020-01至2022-12,21万元,已结题,主持;

3. 中国博士后基金会,面上项目,2020M672008,miR-214通过非经典模式调控酒精性肝损伤的作用机制研究,2020-01至2021-12,8万元,已结题,主持;

联系方式

E-mail:luojiao2012@163.com(常用邮箱)或luojiao@qdu.edu.cn



上一条:李传海 助理教授
下一条:赵坤明 助理教授

关闭