李志强 教授

来源: 发布时间:2021-11-16 09:35:58


  李志强,必威betway西汉姆联网站特聘教授,硕士研究生导师,博士后合作导师,必威betway西汉姆联网站附属医院医员工物研究室主任,生物样本库主任。任青岛市医学会医学遗传学专科分会青年委员会副主任委员。2015年于上海交通大学获生物学博士学位。李志强教授及研究团队致力于复杂疾病的遗传学研究,在相关算法和工具的开发、复杂疾病遗传机制研究等领域取得了一些重要进展,研究成果发表于 Nature Genetics、Cell Research、Ann Rheum Dis、Nature Communications Biological Psychiatry等国际知名期刊。最高影响因子38.33,他引1889次,H-指数16。现作为项目负责人先后主持 2 项国家自然科学基金、山东省自然科学基金省属优青、国家"万人计划"青年拔尖人才等项目,作为第一完成人获青岛市自然科学二等奖,作为前3完成人获上海市及教育部自然科学一等奖、国家自然科学二等奖。


一、主要研究方向

1. 复杂疾病的遗传机制

2. 复杂性状和多基因病的遗传和表观遗传机制

3. 生物信息学


二、代表性科研成果

1. Chen, J.H., Chen, R.R., Xiang, S.Y., Li, N.N., Gao, C.W., Wu, C.H., Zhang, Q., Zhao, Y.L., Liao, Y.H., Stewart, R., Xu, Y.F., Shi, Y.Y.*, and Li, Z.Q.* (2021). Cigarette smoking and schizophrenia: Mendelian randomisation study. British Journal of Psychiatry 218, 98-103.

2. Chen, J.H., Yang, P., Zhang, Q., Chen, R.R., Wang, P., Liu, B.X., Sun, W.S., Jian, X.M., Xiang, S.Y., Zhou, J., Li, N.N., Wang, K., Gao, C.W., Wen, Y.Q., Wu, C.H., Zhang, J.M., Zhao, Y.L., Yang, Q.Z., Li, M.H., Stewart, R., Sun, Y.C., Pan, D., Niu, Y.J., Wang, Z., Xu, Y.F., Li, X.W., He, L., Li, Z.Q.*, and Shi, Y.Y.* (2021). Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study. Translational Psychiatry 11.

3. Chen, R.R., Chen, J.H., Gao, C.W., Wu, C.H., Pan, D., Zhang, J.M., Zhou, J., Wang, K., Zhang, Q., Yang, Q.Z., Jian, X.M., Zhao, Y.L., Wen, Y.Q., Wang, Z., Shi, Y.Y*., and Li, Z.Q.* (2021). Association analysis of potentially functional variants within 8p12 with schizophrenia in the Han Chinese population. World Journal of Biological Psychiatry 22, 27-33.

4. Li, Z.Q.*, Liu, H.L., Chen, J.H., Zeng, T., He, L., Li, M.H., Luo, C.N., Liu, S., Ding, T.T., Yimaiti, K., Teng, J.L., Li, X.W., Ding, Y.H., Cheng, X.B., Zhou, J., Ye, J.N., Ji, J., Su, Y.T., Shi, H., Sun, Y., Gao, C.W., Hu, Q.Y., Chi, H.H., Yuan, X., Zhou, Z.C., Wang, D., Wang, K., Li, C.G., Sun, Y.C., Niu, Y.J., Chen, L.J., Xu, J., Wu, L.J., Zhou, Z.W., Pan, D., Niu, H.T., Shi, Y.Y.*, and Yang, C.D.* (2020). Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals. Annals of the Rheumatic Diseases 79, 161-+.

5. Zhao, Y.L., Xu, Y.P., Wang, X.M., Xu, L., Chen, J.H., Gao, C.W., Wu, C.H., Pan, D., Zhang, Q., Zhou, J., Chen, R.R., Wang, Z., Zhao, H., You, L., Cao, Y.X., Li, Z.Q.*, and Shi, Y.Y.* (2020). Body Mass Index and Polycystic Ovary Syndrome: A 2-Sample Bidirectional Mendelian Randomization Study. Journal of Clinical Endocrinology & Metabolism 105, 1778-1784.

6. Li, Z.Q.*, Chen, P., Chen, J.H., Xu, Y.F., Wang, Q.Z., Li, X.W., Li, C.G., He, L., and Shi, Y.Y.* (2018). Glucose and Insulin-Related Traits, Type 2 Diabetes and Risk of Schizophrenia: A Mendelian Randomization Study. Ebiomedicine 34, 182-188.

7. Li, Z.Q., Chen, J.H., Yu, H., He, L., Xu, Y.F., Zhang, D., Yi, Q.Z., Li, C.G., Li, X.W., Shen, J.W., Song, Z.J., Ji, W.D., Wang, M., Zhou, J., Chen, B.Y., Liu, Y.H., Wang, J.Q., Wang, P., Yang, P., Wang, Q.Z., Feng, G.Y., Liu, B.X., Sun, W.S., Li, B.J., He, G., Li, W.D., Wan, C.L., Xu, Q., Li, W.J., Wen, Z.J., Liu, K., Huang, F., Ji, J., Ripke, S., Yue, W.H., Sullivan, P.F., O'donovan, M.C., and Shi, Y.Y.* (2017). Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nature Genetics 49, 1576-+.

8. Li, Z.Q., Chen, J.H., Zhao, Y., Wang, Y.J., Xu, J.R., Ji, J., Shen, J.Y., Zhang, W.P., Chen, Z.S., Sun, Q.L., Mao, L.J., Cheng, S.L., Yang, B., Zhang, D.T., Xu, Y.F., Zhao, Y.Y., Liu, D.P., Shen, Y.H., Zhang, W.J., Li, C.G., Shen, J.W., and Shi, Y.Y.* (2017). Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea. Nature Communications 8.


三、主要科研和人才项目

1.国家自然科学基金委面上项目,在研,主持

2.国家"万人计划"青年拔尖人才,在研,主持

3.山东省泰山学者青年专家人才计划,在研,主持

4.山东省自然科学基金委省属优青,在研,主持


四、主要科学技术奖励

1.国家自然科学奖二等奖,2019年度,第三位

2.教育部自然科学一等奖, 2019年度,第三位

3. 青岛市自然科学二等奖, 2020年度,第一位


联系方式

E-mail:lizqsjtu@163.com


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